239000008194 pharmaceutical composition Substances 0.000 claims abstract description 59.229920000053 polysorbate 80 Polymers 0.000 claims abstract description 65.239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims abstract description 65.229940068968 Polysorbate 80 Drugs 0.000 claims abstract description 65.235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 66.238000009472 formulation Methods 0.000 claims abstract description 81.239000000203 mixture Substances 0.000 claims abstract description 103.238000000034 method Methods 0.000 title claims abstract description 125.238000004519 manufacturing process Methods 0.000 title claims abstract description 344.108090000623 proteins and genes Proteins 0.000 title claims abstract description 474.102000004169 proteins and genes Human genes 0.000 title claims abstract description 474.235000019421 lipase Nutrition 0.000 title claims abstract description 625.108090001060 lipase Proteins 0.000 title claims abstract description 626.102000004882 lipase Human genes 0.000 title claims abstract description 626.239000004367 Lipase Substances 0.000 title claims abstract description 626.Publication of WO2020023566A1 publication Critical patent/WO2020023566A1/en Links

Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority to US201862703097P priority Critical Priority to US62/703,097 priority Application filed by Merck Sharp & Dohme Corp. Priority date (The priority date is an assumption and is not a legal conclusion. WELSH Original Assignee Merck Sharp & Dohme Corp. Google Patents WO2020023566A1 - Methods of separating host cell lipases from a production protein in chromatographic processes WO2020023566A1 - Methods of separating host cell lipases from a production protein in chromatographic processes

Capto phenyl impres